KAINATE RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION IN THE ADULT ANTERIOR CINGULATE CORTEX Abbreviated title: Forebrain kainate receptor-mediated synaptic transmission
نویسندگان
چکیده
Acknowledgements: Supported by grants from NINDS NS42722, the Canadian Institutes of Health Research, the EJLB-CIHR Michael Smith Chair in Neurosciences and Mental Health, and the Canada Research Chair to M Zhuo. We would like to thank Drs. Stephen F. Heinemann for kindly providing GluR5 and GluR6 KO mice, John F. MacDonald and Geoffrey T. Swanson for providing GYKI 53655 and Michele J. Petrovic for editing this work. Articles in PresS. J Neurophysiol (May 31, 2005). doi:10.1152/jn.00091.2005
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Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex.
Kainate (KA) receptors are expressed widely in the CNS. However, little is known about their functional characterization, molecular identity, and role in synaptic transmission in the forebrain of adult mice. Patch-clamp recordings in genetically modified mice show that postsynaptic KA receptors contribute to fast synaptic transmission in pyramidal neurons in the anterior cingulate cortex (ACC),...
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